Monday, September 30, 2019
Chris Mccandlessââ¬â¢ Death ââ¬ÅInto the Wildââ¬Â Essay
Many people have come to the conclusion that Chris McCandlessââ¬â¢ untimely death was a result of his arrogant nature or a possible psychological disorder. However, his death was caused by a simple mistake, his lack of geographical knowledge, and his desire to find himself. When Krakauerââ¬â¢s moving article in Outside magazine was published, copious amounts of hate mail was received regarding McCandlessââ¬â¢ cause of death. Initially it was believed that he mistook two similar plants, the wild potato and the toxic wild sweet pea, then accidentally poisoned himself when consuming their seeds. Alaskan residents dubbed McCandless as ââ¬Å"ignorantâ⬠and ââ¬Å"unpreparedâ⬠for supposedly confusing the similar plants. After further research Krakauer discovered that McCandless was poisoned by the wild potato plantââ¬â¢s seeds, which were not described as toxic in any published text. This ill-fated blunder does not show incompetence specific to McCandless, as most people would have made the same decisions. There have been scores of young men lacking common sense who wander out into the wilderness to attain meaning and do not return. Several of them, including John Waterman and Carl McCunn, were similar to Chris, but in pivotal ways their stories were deviating. John Waterman was severely traumatized and obviously mentally ill. Chris was neither of those things. Additionally, Chris was not expecting to be rescued after making a dim-witted mistake, like Carl McCunn. Krakauer stated that ââ¬Å"It is not unusual for a young man to be drawn to a pursuit considered reckless by his elders.â⬠Chris may have lacked some common sense, but conceited qualities did not contribute to his downfall. His drive to push himself past his limits contributed to his demise, not superciliousness. Perhaps the most tragic notion of McCandlessââ¬â¢ death is how simply it could have been avoided. Unbeknownst to Chris, there were multiple cabins a few miles from the Fairbanks bus 142. Each was stocked with food and survival supplies. This knowledge could have easily prevented his death. Crossing the Teklanika River was one of the important factors that inhibited McCandless from leaving the wild. He was not aware that downstream in the vicinity of the bus there was a gorge that allowed safe transit across the river. A gauging station was also close by. It would have allowed him to cross the river with ease since hunters had placed the basket on the bus-side of the river. It is overwhelming to imagine the extents to which McCandless suffered physically and mentally, when salvation was so near to him. A simple topographic map would have almost certainly saved his life. McCandless was not arrogant, a sociopath, or an idiot, like so many have stated. He may have lacked the common sense to buy a map, but was in no way incompetent. He also made some mistakes that anyone who was not a trained botanist would have made, and was like many young men in that he pushed himself to the extreme limits. Chris McCandlessââ¬â¢ story is not unique because he ventured out into the unforgiving wild. It is captivating because McCandless gave up everything to find himself, even if he ended up being lost on the way.
Sunday, September 29, 2019
Succubus Revealed Chapter 9
It wasn't until I landed in Seattle on Sunday evening that the full surreal nature of my weekend in Las Vegas hit me. Being there had felt so . . . natural. I suppose part of that was just having old friends like Bastien and Luis around. Yet I'd been pleasantly surprised at how easily I got along with my newer acquaintances, like Phoebe and Matthias. I'd even grown to like Jamie, though I never did see him after that night. Despite my efforts to find him and ask him about Milton, the imp had remained elusive for the rest of my trip. And the show . . . how had that happened? I couldn't even get a solid job here in my current hometown, yet hours after walking off the plane in a strange city, I'd landed what was, in many ways, my dream job. By the time we'd finished our second practice, Matthias was already talking about a special part he planned on creating for me, and several of the other dancers were so disappointed at me leaving for a month, you'd think we'd known each other for years. It had, in spite of my misgivings, been a fantastic weekend. Reality set in when I walked into my condo. Roman was out, with only a note reading Bowling practice tomorrow night to mark his passage. Naturally, the cats were as happy to see me as always. Scratching their heads in turn, I began to think about the logistics of moving both of them with me across state lines. I'd be taking them away from Roman, whom they loved, but there was nothing to be done for that. He couldn't come with us. As a nephilim, he was in constant danger of being hunted down by other immortals, and it was only Jerome's protection that allowed him to have a seminormal life in Seattle. Roman certainly wasn't going to give that up, and besides, Las Vegas was probably the worst place in the world for him to attempt to hide out. A vase of pink-tipped white roses sat on the kitchen table, filling the air with sweetness. I opened up the card and read Seth's scrawled writing: Welcome home. I've been counting the minutes. ââ¬â S I texted him that I was back and received an answer urging me to come over to Terry and Andrea's for dinner. After leaving a note for Roman assuring him I'd be at practice, I headed out, my mind still spinning with more of the consequences of moving. The condo. I'd have to sell it. Unless I wanted to rent it to Roman? Hell would likely compensate any moving costs, but it'd be up to me to start making the actual arrangements now for things like movers and whatnot. I was good at making plans and organizing things, but all of my skills were useless against the one thing I wanted to bring with me to Las Vegas the most: Seth. I still had no solution for what to do with him. I was met with the usual outpouring of love from his nieces when I arrived, just in time for a chaotic family dinner. With the additional family members, they'd given up any pretense of eating at the kitchen table and had simply taken their paper plates and homemade pizza off to the living room. The casualties of food and furniture were ones Terry and Andrea were long since used to, but Margaret couldn't focus on her dinner for fear of constantly watching the girls and what she perceived as imminent tomato-stained disaster. I was happy to see Andrea out with the family, which wasn't something that happened very often lately. She looked tired but was in good spirits, and from the way the girls vied for position next to her, it was clear they were delighted to have her up and around too. ââ¬Å"Seth says you were out of town,â⬠she told me. ââ¬Å"Anywhere fun?â⬠ââ¬Å"Las Vegas,â⬠I replied. ââ¬Å"Visiting friends.â⬠ââ¬Å"Man,â⬠said Ian. ââ¬Å"I wish I had friends in Las Vegas.â⬠ââ¬Å"I figured it'd be too commercial for you,â⬠said Seth, deadpan. Ian swallowed a bite of his pizza ââ¬â it apparently wasn't a vegan day ââ¬â before responding. ââ¬Å"Only if you stay on the Strip and their overpriced luxury hotels. If you poke around in some of the out-of-the-way places, you could find some really cool and obscure dives.â⬠It took nine-year-old Kendall to say what the rest of us were thinking. ââ¬Å"I'd rather stay in luxury. Why would you want to stay in a dive, Uncle Ian?â⬠ââ¬Å"Because it's nonmainstream,â⬠he told her. ââ¬Å"Everyone stays at the nice places.â⬠ââ¬Å"But I like nice things,â⬠she argued. ââ¬Å"Don't you?â⬠ââ¬Å"Well, yes,â⬠he said, frowning. ââ¬Å"But that's not the point ââ¬â ââ¬Å" ââ¬Å"Then why would you want to stay at bad places?â⬠she pressed. ââ¬Å"You're too young to understand,â⬠he said. Seth chuckled. ââ¬Å"Actually, I think she understands perfectly.â⬠Andrea decided to rest shortly after that, but not before extracting a promise that someone deliver her dessert later on. After doing dishes (which was pretty easy with paper plates), our group dispersed into separate activities. Kendall, Brandy, Margaret, and Terry started up a game of Monopoly while Kayla and the twins settled down to watch The Little Mermaid. Ian joined them, excited for the chance to show how the movie was an example of capitalism destroying America. Seth and I curled up on a nearby loveseat, ostensibly to watch the movie, but instead used the time to catch up. ââ¬Å"How was it, really?â⬠he asked me in a low voice. ââ¬Å"I've been worried about you. Was it as bad as you thought?â⬠ââ¬Å"No,â⬠I said, leaning my head against his chest. ââ¬Å"It was actually . . . pretty good. Would you believe I have a job already ? Like . . . one that's not on Hell's payroll.â⬠ââ¬Å"You can't even get one of those here,â⬠remarked Seth. ââ¬Å"Yeah, the irony's not lost on me. I'm going to be a Vegas showgirl, complete with sequins.â⬠Seth trailed his fingers through my hair. ââ¬Å"That's actually kind of awesome. And hot. If you want to practice, I'd be more than happy to give you some constructive criticism.â⬠I smiled. ââ¬Å"We'll see.â⬠There was a long pause. ââ¬Å"So . . . it's real. This whole thing.â⬠ââ¬Å"Yeah,â⬠I said in a small voice. ââ¬Å"It's real.â⬠I felt him tense and sensed the worry radiating off of him. ââ¬Å"It's okay. We'll figure this out. It's still a month away.â⬠ââ¬Å"I know we will,â⬠he said. ââ¬Å"You and I have overcome crazier things than this, right?â⬠ââ¬Å"Crazier doesn't always mean harder,â⬠I pointed out. ââ¬Å"I mean, when Peter tried to make a ââ¬Ëretro candle sconce' out of a Pringles can last month, that was pretty crazy ââ¬â but it was also pretty easy to deal with once we found his fire extinguisher.â⬠ââ¬Å"You see?â⬠said Seth. ââ¬Å"This is what I love about you. I don't even consider that crazy. I consider that ordinary life with you, Georgina. You change all the definitions.â⬠He pressed a kiss to my forehead. We fell silent and watched the movie, though I suspected Seth was paying as little attention as I was. We were both lost in our own thoughts, and I didn't really snap out of it until I heard Ian telling Morgan, ââ¬Å"I like the original fairy tale better. It's pretty alternative, so you've probably never heard of it.â⬠I glanced at the clock and sat up. ââ¬Å"I'm going to go check on Andrea and see if she wants her dessert.â⬠Both Margaret and Terry were quick to offer to do it instead, but I waved them off, assuring them I was fine and that they should return to their game. Andrea was awake, propped up on pillows and reading a book when I came in with the pie. ââ¬Å"You didn't have to do that,â⬠she told me. ââ¬Å"You should've asked Terry.â⬠ââ¬Å"He's busy buying and selling property,â⬠I told her, helping her settle the plate on her lap. ââ¬Å"I couldn't ask him to interrupt that. Besides, he does plenty.â⬠ââ¬Å"He does,â⬠she agreed, smiling wistfully. ââ¬Å"They all do. Even you. It's so strange, having others take care of me. I'm too used to looking after everyone else.â⬠I settled down on a chair near her bed, wondering how often it must be filled lately. Andrea always had someone watching over her. ââ¬Å"It's just for a little while longer,â⬠I said. That got me another smile as she chewed a bite of pie. ââ¬Å"You're very optimistic.â⬠ââ¬Å"Hey, why shouldn't I be? You look great today.â⬠ââ¬Å"Great ââ¬Ëironically,' as Ian would say.â⬠She ran a hand through her limp blond hair. ââ¬Å"But I do feel better than I have for a while. I don't know. It's deceptive, Georgina. There are days I feel confident I've beat every cancer cell in my body and others when I can't believe I'm still managing to walk this earth.â⬠ââ¬Å"Andrea ââ¬â ââ¬Å" ââ¬Å"No, no, it's true.â⬠She paused for more pie, but her eyes took on a vast, knowing look that reminded me eerily of Carter. ââ¬Å"I've accepted it, come to terms with the fact that there's still a good chance I'll die. No one else has. No one else will talk about it. I'm okay with that. If that's what God wills for me, then so be it.â⬠I felt a knot clench in my stomach. I couldn't say much about God, but I'd seen enough of Heaven and Hell to get angry when I heard humans accept their fate as part of some higher purpose. Half the time, it seemed to me the divine powers were making up this game as they went along. ââ¬Å"I'm not worried about me,â⬠Andrea continued. ââ¬Å"But I am worried about them.â⬠That serenity faded, replaced by very real human concern, a mother's fear for her children. ââ¬Å"Terry's strong. So wonderfully strong. But this is hard on him. He can't do it alone, which is why I'm so glad Seth's here. I don't know what we would have done without him. He's the rock supporting us all right now.â⬠The anxiety inside me eased for a few moments, replaced by a spreading warmth as I thought about Seth. ââ¬Å"He's wonderful.â⬠Andrea set down the fork, finished, and extended her hand to me. ââ¬Å"So are you. I'm glad you're part of our family, Georgina. If something happens to me ââ¬â ââ¬Å" ââ¬Å"Stop ââ¬â ââ¬Å" ââ¬Å"No, listen. I mean it. If something happens to me, I'll rest easy knowing the girls have you in their lives. Seth and Terry are great, but the girls still need a strong woman role model. Someone to help them through growing up.â⬠ââ¬Å"I'm not that good of a role model,â⬠I said, not meeting her eyes. I was a creature of Hell, someone full of weakness and fear. What could I possibly have to offer such bright, promise-filled creatures like the Mortensen girls? ââ¬Å"You are,â⬠said Andrea adamantly, squeezing my hand. ââ¬Å"They love you and admire you so much. I know they're in good hands.â⬠I swallowed back tears that were threatening to overwhelm me. ââ¬Å"Well,â⬠I said. ââ¬Å"They're in even better hands with you, since we all know you're going to get well soon.â⬠Andrea nodded, giving me an indulgent smile that I suspected she'd perfected after weeks of listening to others insist she was on the verge of recovery. A yawn soon betrayed her, and I carefully took the plate away and asked if she needed anything else. She assured me she didn't. I crept back downstairs and returned the plate to the kitchen, where I found Brandy and Margaret eating pie of their own. I did a double take back toward the living room. ââ¬Å"What happened to Monopoly?â⬠ââ¬Å"Kendall bought us out,â⬠said Margaret. ââ¬Å"Man, I hate playing with her,â⬠grumbled Brandy. ââ¬Å"No one her age should be that good.â⬠ââ¬Å"Don't knock it,â⬠said Seth, strolling in. ââ¬Å"She's going to be supporting us all in fifteen years.â⬠He rested a hand on Brandy's shoulder. ââ¬Å"Did you ask Georgina?â⬠Brandy looked at her feet. ââ¬Å"No.â⬠ââ¬Å"Ask me what?â⬠ââ¬Å"It's nothing,â⬠she said. ââ¬Å"Clearly it's something,â⬠I replied, exchanging looks with Seth. ââ¬Å"What's up?â⬠ââ¬Å"Is this the Christmas dance you were talking about before ?â⬠asked Margaret. Brandy flushed. ââ¬Å"A holiday dance. It's nothing.â⬠ââ¬Å"No way,â⬠I said. ââ¬Å"I'm a big fan of dances. But isn't school out?â⬠ââ¬Å"Yeah, but this is at church. It's a formal they have every year.â⬠She was using a It's no big deal tone, but her expression betrayed how interested she was. The church part surprised me, since last I knew, the Mortensens didn't attend one. But obviously that had changed. Maybe Andrea's illness had played a role. Whatever it was, I could see faith wasn't on the line here, so much as a teenage girl's simple desire to participate in something fun with other people her age. It was a normal rite of passage, one I was guessing she didn't feel worthy of, in light of everything else going on right now with her family. No wonder she was hesitant to mention it. I wondered if maybe there was a boy involved too but certainly wasn't going to ask. She looked mortified enough to be having this discussion in front of her uncle and grandmother. ââ¬Å"You need to shop for a dress?â⬠I guessed. People always called me for shopping. I used to be bothered by that but then figured I should accept what I'm good at. Brandy nodded, still looking embarrassed. ââ¬Å"When is it?â⬠ââ¬Å"Tuesday.â⬠ââ¬Å"Tuesday . . .â⬠I frowned, thinking of my schedule. Tomorrow, Monday, was taken up with work and bowling practice. That didn't leave a lot of time. ââ¬Å"We might be cutting it close.â⬠ââ¬Å"If you don't have time, it's fine,â⬠Brandy assured me. ââ¬Å"Really.â⬠ââ¬Å"No way,â⬠I told her. ââ¬Å"We can do it Tuesday morning.â⬠Brandy looked down again. ââ¬Å"My dad can pay you backâ⬠¦. I'll ask him how much we can spend.â⬠ââ¬Å"Forget it,â⬠said Seth, rustling her hair. She squirmed out of his reach. ââ¬Å"Send the bill to me. You know where I live.â⬠Brandy protested this, but Seth was firm in his offer ââ¬â as well as his urging that Brandy not mention it to her father. But once Brandy and Seth were in the other room, Margaret caught hold of my sleeve and pulled me back into the kitchen before I could follow. Our interactions hadn't exactly been antagonistic (aside from our initial meeting with the baseball bat), but they hadn't always been pleasant either. I braced myself for some admonishment about dressing Brandy like a whore. ââ¬Å"Here,â⬠said Margaret, shoving some cash into my hands. I looked down and found two fifty-dollar bills. ââ¬Å"Seth's not the only with income around here. He can't keep funding the whole family. Is that enough for what she needs?â⬠ââ¬Å"Er, yes,â⬠I said, trying to hand it back. I'd actually planned on cutting Seth out as well and carrying the bill myself. ââ¬Å"Definitely. You don't have to do this.â⬠Margaret's response was to give me another bill. ââ¬Å"Get her shoes too.â⬠She closed my hand around the cash. ââ¬Å"I don't know what girls her age need when it comes to clothes, but I know you do. The money I can provide. The rest I rely on you for.â⬠That sentiment ââ¬â that faith in me ââ¬â was too much, too fast on the heels of the conversation I'd just had with Andrea. ââ¬Å"It's not enough,â⬠I blurted out. ââ¬Å"What I'm doing, compared to everyone else. They're all giving so much. What's a shopping trip next to that?â⬠Margaret fixed me with a piercing gaze that bore no resemblance to the conservative, sweatshirt-wearing matron I'd categorized her as. ââ¬Å"For a girl growing up too fast, whose life is crumbling around her? Everything.â⬠ââ¬Å"I hate this,â⬠I said. ââ¬Å"I hate that this is happening to them.â⬠ââ¬Å"God only gives us what we have the strength to endure,â⬠she said. I'd always hated that saying, largely because it too seemed to go along with the idea of a universe having a plan for everyone, something I'd seen no evidence of. ââ¬Å"They have the strength to get through this. And they have our strength to help them.â⬠I smiled at that. ââ¬Å"You're a remarkable woman, Margaret. They're lucky you're here.â⬠I meant it. She and I might have different philosophies about premarital sex, but her love for them was undiminished. I wasn't the only role model in the girls' lives. She shrugged, looking both flattered and embarrassed by my praise. ââ¬Å"Like you, I'm just trying to do enough ââ¬â without wearing out my welcome at Seth's.â⬠ââ¬Å"He loves having you,â⬠I said promptly. She rolled her eyes. ââ¬Å"I'm not stupid. I want to keep helping, but I know I can't stay with him forever. He's a grown man, no matter how much I'd like to pretend otherwise.â⬠That made me smile even more. ââ¬Å"Don't worry. I won't tell him you said so.â⬠Nonetheless, I went home with a heavy heart that night. Seth expected to be up late and hadn't wanted me waiting around for him. We were both conscious of how little time we'd had together recently, though, so he told me he'd join me for tomorrow night's bowling practice. As a general rule, he tried to avoid immortal goings-on, but I think he had a morbid fascination with the idea of bowling for Hellish honor. ââ¬Å"Thank God,â⬠said Roman, when I walked in the door. ââ¬Å"I thought you were going to stay at Seth's. There's soup on the stove.â⬠ââ¬Å"No, thanks,â⬠I said. ââ¬Å"I already ate.â⬠ââ¬Å"Your loss,â⬠he said. Judging from the way the cats were circling him for handouts as he settled down on the couch with a bowl, I guess they agreed with him. ââ¬Å"How was it?â⬠My mind was still on the Mortensens, and for a moment, I thought that's what he meant. Then I remembered his single-minded focus and knew he was referring to Las Vegas. ââ¬Å"Surprisingly good,â⬠I told him, sitting down in an armchair. His eyebrows rose. He hadn't expected that answer. ââ¬Å"Oh? Tell me about it.â⬠I did, and he listened attentively while eating his soup. When I'd finished the weekend's recap, he grilled me on nearly everyone I'd met there, immortal and mortal alike. In two days, I didn't have that much life history to report but gave him what I could. ââ¬Å"Well,â⬠he said, ââ¬Å"isn't that lovely.â⬠He made no effort to hide his sarcasm. I sighed. ââ¬Å"You still think this was part of some greater conspiracy ?â⬠ââ¬Å"I think it's terribly convenient that this seemingly routine transfer is fulfilling every possible wish you might have.â⬠I scoffed. ââ¬Å"Aside from the fact that I'm being transferred in the first place. That's hardly something I wanted.â⬠Roman straightened up, and the cats ran for his abandoned bowl. He ticked off points on his right hand. ââ¬Å"Well, let's do a tally, shall we? When I first met you, I asked what your dream job would be. What did you say? A Vegas dancer. And wow! Look what conveniently falls into your lap. And who put it there? In a city full of conniving, backstabbing succubi, you were fortunate to find one as levelheaded as you, complete with the same sense of humor and interests. Funny thing . . . did you even run into any other succubi that entire weekend? In a city packed with them?â⬠ââ¬Å"Roman ââ¬â ââ¬Å" ââ¬Å"No, no, wait. There's more. How'd you meet this wonder succubus anyway? Through your closest immortal friend, who just happened to have been coincidentally transferred to Las Vegas, hired on by your favorite boss of all time. Are you following this fantasy so far?â⬠ââ¬Å"But why would ââ¬â ââ¬Å" ââ¬Å"And,â⬠he continued, ââ¬Å"lest you grow homesick for the wacky idiosyncrasies of your friends back here, Vegas is ready to supply you with new ones. A zany drunken imp. Seth 2.0. If you'd stayed longer, they probably would have unearthed an angel and a couple of vampires for you. And let's not discount the fact that you're going to Las Vegas in the first place! The single easiest place for a succubus to get by.â⬠ââ¬Å"Okay, I get what you're saying.â⬠I threw up my hands in exasperation. ââ¬Å"It is perfect. Maybe too perfect. But you're missing one fundamental point. Supposing this is true, that someone has set up the most perfect scenario for me ever, a situation designed to keep me happy, why would they do it at all when the thing that would make me the most happy is to stay in Seattle? Why bother with this alternative? Why not leave me as I am?â⬠Roman's eyes gleamed. ââ¬Å"Because that's the one thing they don't want you to have. They want you out of Seattle, Georgina. They want you out, and they don't want you to complain or look back.â⬠ââ¬Å"But why?â⬠I protested. ââ¬Å"That's what I can't figure out.â⬠ââ¬Å"Give me something else to work with,â⬠he said. ââ¬Å"Hell's not that good. Even the most picture perfect setup has to have a flaw. Was there anything, anything at all this weekend, that felt disingenuous? That smacked of a lie?â⬠I gave him a wry look. ââ¬Å"I was in Las Vegas, hanging out with servants of Hell. Everything was disingenuous.â⬠ââ¬Å"Georgina, think! Anything that seemed legitimately odd. Any contradiction.â⬠I started to deny it but then paused. ââ¬Å"The timeline.â⬠He leaned forward even more. ââ¬Å"Yes? What about it?â⬠I thought back to my first hours in Las Vegas. ââ¬Å"Luis and Bastien both went out of their way to act as though my transfer and Bastien's had been in the works for a while ââ¬â like Jerome said. But once, Bastien slipped. He sounded like he hadn't been there for very long at all ââ¬â not nearly as long as they'd said before.â⬠ââ¬Å"Like that maybe he was suddenly pulled in on a moment's notice ââ¬â to coincide with your transfer?â⬠ââ¬Å"I don't know,â⬠I said, not liking the thought of Bastien being part of some potential conspiracy centered around me. ââ¬Å"He corrected himself, said he misspoke.â⬠ââ¬Å"I'm sure he would say that.â⬠Roman leaned back now, letting all of this sink in. ââ¬Å"Bastien wouldn't lie to me,â⬠I snapped. ââ¬Å"He's my friend. I trust him. He cares about me.â⬠ââ¬Å"I believe you,â⬠said Roman. ââ¬Å"And I believe that he wouldn't lie to you about something that he thought might harm you. But if his higher-ups asked him to tell a white lie ââ¬â fudge a few days here and there ââ¬â don't you think he would?â⬠I nearly denied it ââ¬â but then had to wonder. Bastien had been in trouble off and on with our superiors, his Seattle venture last year a desperate attempt to restore status. If he were pressured enough ââ¬â threatened, even ââ¬â to tell me he'd been transferred longer than he actually had, would he? Especially if he thought it was harmless and knew of no nefarious reason behind it? ââ¬Å"But what nefarious reason would be behind all this?â⬠I muttered, not realizing I'd spoken my thoughts aloud until Roman straightened up again. ââ¬Å"That's what we have to figure out. We have to figure out what's happened to you that would've gotten someone's attention ââ¬â and that happened recently, to spur such a fast response. We know about your slacker record. And we know about Erik looking into your contract.â⬠I blinked. ââ¬Å"Milton.â⬠I quickly told Roman about Hugh's information, about Milton's secret assassin status and trip to Seattle lining up with Erik's death. I also told him about briefly mentioning Milton to Jamie. Roman leaped to his feet. ââ¬Å"Jesus Christ! Why didn't you tell me about this sooner? I could've investigated Milton while you were gone. Shit. Now I'm trapped here under bowling duty.â⬠Nephilim had the same travel limitations as lesser immortals. They had to physically travel to places. No teleportation like greater immortals. ââ¬Å"I'm sorry,â⬠I said. ââ¬Å"I wasn't thinking. I didn't connect it. And I didn't get a chance to ask Jamie more about Milton. He wasn't around the rest of the time I was in town.â⬠Roman was nodding along with me as he paced. ââ¬Å"Of course he wasn't. I'm sure they made certain he was unavailable before he could tell you any more. And explain again why your initial conversation with him didn't go that far?â⬠I shrugged. ââ¬Å"He was drunk. He got distracted by a debate over gin with Luis.â⬠ââ¬Å"One that Luis initiated, no doubt.â⬠ââ¬Å"I ââ¬â â⬠I thought about it. ââ¬Å"Yeah. I guess he did. But you're not saying . . . I mean, that's idiotic. Using gin as a distraction to cover up some plot?â⬠Roman's sea green eyes were gazing off in the distance, thoughtful. ââ¬Å"It's not the most ridiculous distraction I've known a demon to use. He could've brought up bowling.â⬠ââ¬Å"Not that again.â⬠Roman snapped his attention back to me, frustration all over his face. ââ¬Å"Georgina, how can you be in denial about this? How can you refuse to believe that Hell is playing some larger game here? After all you've seen and been a part of?â⬠I shot up, angry at the insinuation that had been creeping along here, that I was too oblivious to see what was going on. ââ¬Å"I know! I know they're capable of it. I know they can use means both ingenuous and simple ââ¬â like gin and bowling ââ¬â to get what they want. I'm not denying that, Roman. What I just can't grasp yet is the why. Show me that, and I'll get on board with any crazy scheme you want. I need to know why.â⬠Roman came to stand in front of me, resting his hands on my shoulders as he leaned close. ââ¬Å"That is exactly what I intend to find out. And when we do, I have a feeling we'll have blown the lid off of the biggest conspiracy Hell's had in centuries.ââ¬
Saturday, September 28, 2019
A study of the characters Odysseus and Poseidon as depicted in Homers Odyssey
A study of the characters Odysseus and Poseidon as depicted in Homer's Odyssey After the events of the Trojan War, Odysseus and his men headed back home to Ithaca. En route, they unknowingly stopped at the island of the Cyclopes to gather supplies for their long journey home. Unfortunately, the inhabitants of the island were not very friendly ââ¬â particularly one Cyclops named Polyphemus. In an attempt to hide from the other giants, Odysseus and his men hid in Polyphemusââ¬â¢s cave. Polyphemus then trapped the men inside with a massive boulder blocking the only way in and out. One by one, Polyphemus ate Odysseusââ¬â¢s crew. Odysseus, keeping a level head, came up with a plan to escape. Odysseus had some undiluted wine on his person, and cleverly offered it to Polyphemus without telling him how strong the wine was. Polyphemus eagerly took the wine, became drunk, and promptly fell asleep. Odysseus and his remaining men heated a wooden stake in a fire, and proceeded to blind Polyphemusââ¬â¢s one eye. After howling in pain, the men hid under the giantââ¬â¢s sheep, where they could not be felt and eaten. The next morning, when Polyphemus let his sheep out to graze, Odysseus and his men snuck out underneath the sheepââ¬â¢s wooly bellies, and escaped to their ship. Polyphemus realized that the men had escaped after Odysseus was already at sea. Polyphemus threw a (poorly-aimed) boulder at the ship, and called out to his father Poseidon for vengeance. Poseidon, in his rage, destroyed Odysseusââ¬â¢s ship, as well as his entire crew, over a ten-year journey back to Ithaca. Odysseus only survived becaus e he had Athenaââ¬â¢s favor and protection. Odysseusââ¬â¢s Argument: Odysseus was acting out of self-defense. As captain and king, he had a duty to protect himself and his men at all costs. He used his wits to escape a life-threatening situation. He also did not know that Polyphemus was son of Poseidon. Regardless of who Polyphemus was, Odysseus did not kill him, despite the threat against Odysseus and his crew; it would have been just as easy to kill him while drunk or asleep. Poseidon, being a god, acts out of extreme emotion, and decides that the injury of his son warrants mass-murder. Odysseus thought rationally and spared the man-eating Polyphemus; Poseidon acted irrationally, and eradicated Odysseusââ¬â¢s crew. Poseidon could have been more merciful and wiped out Odysseus and his crew quickly. Instead Poseidon extended Odysseusââ¬â¢s punishment and caused him to suffer as he watched his entire crew die over the course of ten years. Furthermore, this extended journey caused turmoil in Odysseusââ¬â¢s Kingdom of Ithaca. When Odysseus left for Troy, his son, Telemachus, was too young to take the throne. This left Penelope running the entire country. While Odysseus was gone, suitors came to court Penelope, raiding his palace while they were there. Since there was no proof that Odysseus survived the Trojan War, the suitors constantly pressured Penelope to remarry. She did not want to, instead stalling the suitors until Odysseus returned because she believed that he was still alive. Poseidonââ¬â¢s Argument: Before Poseidon did anything to Odysseus, he had to get his idea approved by Zeus, king of the gods. Furthermore, Odysseus was in Poseidonââ¬â¢s domain, the ocean, for most of his journey, which puts Odysseus in a precarious position already. Poseidonââ¬â¢s intended target was Odysseus; the rest of the crew was collateral damage, but also emotionally hurt Odysseus. Odysseus knew he was in the domain of a deity that could wreck him on every level; he had plenty of opportunities to brace himself in case things went wrong. Poseidon, as a deity, demands more respect than a typical human. In Poseidonââ¬â¢s mind, this special treatment extends to his son. Injuring his son Polyphemus was considered a personal insult. Unknown to Odysseus, he had divine protection from Athena ââ¬â a rival deity to Poseidon. Therefore, Poseidon already did not like Odysseus; stabbing Polyphemus in the eye just added to Poseidonââ¬â¢s hatred. Poseidon did not harm Odysseus, but made him suffer, just like his son, by killing his men slowly. Let the punishment fit the crime. Moreover, there are times when Odysseus was not only selfish, but genuinely irreverent. While Penelope was upholding her marriage vows, Odysseus had an affair with Circe, a sorceress who had turned his men into pigs while he had his fling. He also deliberately went past the island of the Sirens, just because he wanted to hear their song for himself. Finally, he allowed his men to eat sacred cattle of the god Helios for a week. This one act condemned his entire fleet, ship and men, to destruction. Zeus struck the ship with lightning, forcing Odysseus to swim to an island and live with a Calypso, a sea nymph, for seven years. The rest of his men drowned. This shows that Odysseus did not always respect the gods, and acted selfishly whenever it suited him.
Friday, September 27, 2019
Marketing Manager Research Paper Example | Topics and Well Written Essays - 2000 words
Marketing Manager - Research Paper Example The F-16 was initially developed by the company General Dynamics, however General Dynamics sold its aircraft manufacturing facilities to Lockheed Martin and it has since been marketed by them. With the current race of weapons technology, it is also not deniable that management of the F-16 at Lockheed Martin will do very well to keep it relevant in the latest war arenas and war deterrence mechanisms of the world. In its field of work, the F-16's fate really depends on its manufacturers being able to keep it competitive with other aircraft of its role in terms of functionality. Functionality, Time, Place and Ease of Possession As stated in the previous statement the crucial feature for the F-16 as a product is the state of its functionality. Upgrading the F-16 has been vital in keeping it competitive. Unfortunately upgrading any product can never produce the same results as incorporating a technology in the design process of the product. There have been a few issues reported in latest block of type C/D aircraft. This is because the upgrading process is being severely hindered by technical complications due to the advent of sophisticated avionics software. One limitation on the upgrades has been the limited power and cooling capabilities of the aircraft, which have been stretched thinner in more advanced variants with more power hungry avionics (Hartung, 2011). With regard to the time requirements of the customer, the F-16 has been one of the most effective weapons ever developed. In fact it was the answer to the United States military's question of what it was to do about air superiority and air-to-air combat after the experiences of the Vietnam war. And even now it is said that production of the F-35 Lightning II, Lockheed Martin's current flagship aircraft has been suffering from the company's focusing resources on meeting customer demand for the F-16. Delivery of aircraft to the customer is a trivial matter in projects of complex military weapons development. In any case the operations of distribution are kept clandestine by the Supply Chain management. In fact according to Schultz (1993), "With the rise of Internet and hybrid models of purchasing, Place is becoming less relevant" even in mainstream product marketing models. Unfortunately Lockheed has not fared well in the past in dealing with customer countries' representatives in terms of displaying teamwork. It ranks number one on the 'contractor misconduct' database maintained by the Project on Government Oversight, a Washington DC-based watchdog group. However for the upgraded F-16s' program the company is looking to institute a culture of cooperation with the clients' right of possession and providing efficient technical assistance as stipulated in the contracts with the foreign defence forces. For better cooperation with international clients the company will be designating Program managers for each countries' F-16 delivery programs. The program managers will be responsible for th e execution of the entire program: contract award, design, build delivery and post delivery sustainment. They will work with a variety of customers on multiple contracts including end item delivery, design enhancements, support and training. Customer Base for the F-16 The target market has obviously shifted away from the United States in the past decade and into some other developed countries of the world. However, now the company will
Thursday, September 26, 2019
The National Trust for Scotland (NTS) Essay Example | Topics and Well Written Essays - 1000 words
The National Trust for Scotland (NTS) - Essay Example The properties that are handled by the National Trust of Scotland are quite diverse ranging from castle to cottages. They also look after the birthplaces of famous Scots like Robbie Burns and taking care of the industrial heritage sites such as Lanark Mills also comes under their responsibility. Other than this, the Trust also takes care of over 200,000 acres of countryside including farmlands, mountains and moorlands, farmland forest, waterfalls, coastlines, and island (Countryhouses, 2010) Despite having such a great responsibility, the National Trust of Scotland has been ignoring its prescribed duty thus; it has to face the financial reality of their mistakes. These mistakes have somehow far- reaching consequences of its houses (Countryhouses, 2010). Marketing Proposal Mix The proper use of 7 Ps is very essential for internet marketing and when used properly, they can make a significant difference in online business. Therefore, to attract customers for the Trust, management should understand these policies and use them for the following reasons. Increase website traffic: To increase the internet traffic, the language used by the website must be easy and comprehendible to the viewers. By using the promotional strategies for the trust on the web, and advertising the places for the trust, you can surely gather the potential customer. The basic idea behind the increase in the traffic of website is to have an effective content on the site. Keeping in mind the element of people and place from the marketing mix, the trust should hire competent people who can make the site interactive for the user. It can also be done by making small a documentary on the places they handle (Snack, 2011). This might increase the budget of hiring but it can be recovered when business will be generated The other way to increase traffic on the site is to utilize the place, website, properly. Let people share information and their experiences about the trust places. Through this, the pro cess will be enhanced; they will remain engaged with the website and will come to know about the recent updates and offers made by the trust. Moreover, the management should keep on changing the features and content of the site so the user does not feel monotony. The anticipated outcome from these activities is to increase the viewership and the traffic on the site with little expenditure from the budget (Snack, 2011). Followers become advocates for the trust People who are passionate about the trust can become its best advocate. They can only become loyal customers if the Trust manages to give them the services they have promised them online. The Trust can make people their advocate if they manage to provide incentives to the people who will bring other customers for the Trust. These incentives can depend on the ratio of the business that they are bringing in; these customers can get free tickets to a national place or they can get discount of some events they want to hold in the T rustââ¬â¢s property. Through the proper planning, with very little investment the trust can play with Product and Pricing for the Promotion. The anticipated outcome form this is; the Trust can gain more customers with little investment. Thus, it will raise the income column of the budget sheet. Visit national Trust of Scotland or purchase from online store: It is generally
Family Court of Western Australia Essay Example | Topics and Well Written Essays - 2000 words - 1
Family Court of Western Australia - Essay Example Court Officials and Counselling Service Staff of the Court gained new insights and skills in these very complex scenarios of family break-ups and litigation. The need to liase more closely with internal as well as outside service providers, such as counsellors, social workers, psychologists, and other experts, brought a greater feeling of common purpose and it was soon clear that a potential model of an integrated family court system was beginning to emerge. The Family Court of Australia was intended to be seen as a ââ¬Å"helping courtâ⬠with an informal and user-friendly approach, but this soon changed as formalising occurred naturally in response to intense emotional circumstances which would inevitably arise in cases of family especially where prevailing legal activities tended to result in adversarial stances on the part of litigants. It was felt that the system was still limited and the Family Court on its own could not achieve outcomes that would benefit all parties, but particularly the children. In view of the growing number of applications for divorce and threat of disintegration of society, it was felt that greater use should be made of professionals from the social sciences, including psychologists, social workers, and child specialists.
Wednesday, September 25, 2019
Proposal on Strategic Human Recourse Management Essay
Proposal on Strategic Human Recourse Management - Essay Example Master of Business Administration 2011/2012 Business Issue Report Name: Word count: 1941 This work is copyright of the author. ... The proposal also discusses about the various previous literatures that have discussed about the topic under study in the past. The paper also includes the use of different methodologies that has been adopted in the research. The methodologies include the use of primary and secondary sources for data collection for the purpose of analysis of the research. The survey and interview method will be used for the purpose of primary data collection and the review of the several literary sources as been utilized for the purpose of collecting the secondary data. The proposal also includes reflection statement with respect to the potential and practical problems that have been faced while performing the research. The reflection also includes the theoretical and conceptual problems faced by researcher during the research. Finally a conclusion is drawn based on the overall research, and discussing the next steps that need to be taken. Introduction Aim/ Focus The main aim and focus of research st udy is on the use of training and development in the immigration police department in order to address the building and development of the culture in the organization and bring in new insights in the department with respect to improving the current practices (American Society for Training and development 1987). This focus will be effective to explore the impact training and development also to determine the way through which the immigration police department will benefit from these practices. Dissertation Topic: ââ¬Å"Training and Development: Immigration Police Department in Cyprus.â⬠Main Research Question: How does the employee development and
Tuesday, September 24, 2019
How to solve the problem of long waiting lines in public schools Assignment
How to solve the problem of long waiting lines in public schools - Assignment Example Such an implementation would reduce the waiting duration for young children before they get keep in touch with their parents considering that children might not withstand long duration in queues. In order to reduce congestion that is characterized by long parking lines that attribute to congestions within school compounds, a policy should be implemented that restrain parents from packing within school compounds to the back yard of the institution. Besides, students should be dismissed based on grading criteria as it would improve chances of the parental accessibility to their children in good time. Similarly, it is advisable for students who are using the school bus to board according to their grades. As such, only students whose grades have been read should be allowed to board. If the above implementations are followed then there is maximum possibility that the problem of long waiting lines in public schools shall be solved (Deneen & Catanese,
Sunday, September 22, 2019
Economics Essay Example | Topics and Well Written Essays - 500 words - 2
Economics - Essay Example Due to current civil unrest in Bahrain and neighboring locations there are no current statistics available. However, the rate of inflation in 2010 was 3.3% which was up sharply from the reported 2.8% in 2009. One author from the Wall Street Journal wrote, ââ¬Å"In its statement, Egypt's Central Bank said deteriorating regional political circumstances, including a civil war in Libya as well as violence in Syria, Yemen and Bahrain, could drive up oil prices and further slow the continuing global economic recovery.â⬠(Bradley) The Bahrain Economic Development board is positive in the most recent release, ââ¬Å"In Q4 2010, the Bahrain economy is expected to post similar growth to that seen in the third quarter growthâ⬠¦over 4%â⬠(Bahrain Economic Quarterly p. 4). Overall there is growth occurring especially in the tourism section as oil only accounts for approximately 15% of the economic outlook. With the civil unrest and potential for continuing problems there may be a d rop in tourism as a result. It will be necessary to see what the results are before making long term forecasts. Bahrain Economic Quarterly, . "Bahrain 2030, Bahrain Economy." Bahrain Economic Development board. N.p., First Quarter 2011. Web. 28 Apr 2011. http://www.bahrainedb.com/uploadedFiles/Bahraincom/BahrainForBusiness/BEQ%20Q1%202011.pdf Bradley, M. "Egypt Central Bank Keeps Key Interest Rates Unchanged ." Wall Street Journal. Dow Jones and Company, 28 April 2011.
Saturday, September 21, 2019
How the Digital World May Change Essay Example for Free
How the Digital World May Change Essay The rapidly changing societies with constantly improving technology and occurrence of social digital technologies dramatically changed the way people communicate and interact with each other making them either ââ¬Å"digital nativesâ⬠, ââ¬Å"digital residentsâ⬠, ââ¬Å"digital immigrantsâ⬠or ââ¬Å"digital visitorsâ⬠based on their generation or familiarization with technology. More and more people today perceive the world as the complicated and mature network of computerized and online applications that help to communicate, search for, exchange and share information, make business with international partners, play games on distance, and many other purposes. Though, the question is whether digital natives and digital residents are the same in their perception of the world, behavior and life habits in the future? Behavior of Digital Residents Since personally I was born before 1994, I am related to the category of digital residents, who were born before the occurrence of social digital technologies. Such people like me learnt the computer and Internet-related skills either in schools or universities and have an opportunity to compare life and perception of the world before and after the digital world. Despite I am not a digital native, my behavior as a digital resident is already influenced by numerous technologies I am using daily like cell phone, computer, DVD player, iPod, etc. With occurrence of cell phones, for example, people became more flexible and mobile in their behavior, actions, plans and ability to communicate with their family members, friends and colleagues. Moreover, many people combine conversations by cell phone with other activities like cleaning the house, working on the computer, shopping or driving a car (Palfrey and Gasser, 2008). Recently more and more people, including me, prefer to make their personal or business calls while driving to the office, shop or gym. It might be a good way to use time efficiently, though at the same time might cause problems and distract a person from driving and being careful on the road. In one of his first video chapters Robert Schrag (2010) addressed exactly this issue when young people got used to talk by phone and type text messages while driving. Though, the main difference in such behavior between digital natives and digital residents is that the last ones are more careful, reasonable and less dependent on the technologies than digital natives are (Palfrey and Gasser, 2008). It might sound crazy, but computers, cell phones and other technology-related products became a mandatory and integral daily part of their lives. While as a digital resident I am less dependent, or better to say, obsessed with technology, the changing world of education and business requires being constantly aware and familiar with the latest technologies, either to learn the updated and useful information for my personal and professional development or to keep pace with younger people whose knowledge of languages, computers and technology-related applications make them more competitive at the labor market. Conclusionà As for the future behavior as a digital resident, it is rather hard to predict since more and more innovations enter our lives. For example, nowadays a debate exists concerning two main issues: human cloning and brain chips. Personally, I do not support either of these ideas since with their occurrence and legacy people will be controlled by those who created such innovations while the human being is independent self-thinker who is responsible for his/her own actions, has personal wishes and dreams and is unpredictable in his/her behavior. While digital world gives me more and more opportunity to learn the world and communicate with other people, at the same time it controls me more and more shaping my behavior in the way innovators and digital world creators want. I personally think that technology should be wisely and within certain limits without suppressing and eliminating the natural things and personal communication between people.
Friday, September 20, 2019
How Does Diversity and Immigration Impact Innovation?
How Does Diversity and Immigration Impact Innovation? Anca Pop Nowadays, due to the increasingly competitive economic environment, and the constant danger of economic turn-downs, innovation has come into great prominence not only as an important source of competitive advantage, but also as a powerful driver of economic growth and prosperity. In this new context, attention has been drawn to the role that cultural diversity and immigration play in fostering innovation. Thus, the aim of this essay is to assess the impact of immigration on innovation. Furthermore, the question regarding whether or not a culturally diverse society represents an enabling environment for innovativeness shall be discussed. Nevertheless, a number of evidences and empirical data which support the linkage between cultural diversity, immigration and the innovation process shall be analysed. Statistical reports have shown that at the turn of the century ââ¬Å"4.6% of world population was born in a different country from the one where it currently livedâ⬠. (Bratti and Conti, 2012:2). Given the size of this phenomenon, immigration has come into sharp focus on the global agenda, currently being at the centre of many economic and political debates and its economic consequences giving rise to a high level of research activity. Thus, it would be of highly importance to consider the contribution of increasingly cultural diversity in many societies to the innovation system especially when dealing with economic analysis and policy. However, in order to be able to analyse the effects of immigration and cultural diversity on innovation, firstly, the meaning of ââ¬Å¾innovationâ⬠as a concept along with its indicators should be tackled. Defining ââ¬Å"innovationâ⬠could be rather a difficult task as it is a ââ¬Å"multi-faceted phenomenonâ⬠, and a widely used concept in various ways and different contexts. (Venturini, 2005: 1) However, it could be generally agreed that â⬠Innovation is different from pure invention. Innovation involves the successful implementation of a new product, service or process, which for most activities entails their commercial success.â⬠(Gordon and McCann, 2005: 3). In addition to this, Ozgen, Nijkamp and Poot (2013: 3) state that innovation is achieved ââ¬Å"by means of analytical knowledgeâ⬠and argue that ââ¬Å"The improvement of an existing product or the modification of an existing process or organizational arrangement can also be viewed as an innovation.â⬠Regarding the measures of innovation, the most prominent ones are the number of patent applications and the Total Factor Productivity, used as proxies of technological growth and effective innovation s at both firm and country levels. Having now defined this process, leads the analysis further, to establishing how does immigration affect innovation. In recent years, research activities have demonstrated a rather positive correlation between migration and innovativeness, as ââ¬Å"individuals coming from different countries usually have different, complementary skills with respect to natives, and the production of new ideas may be positively influenced by contacts and interchanges between culturally diverse individualsâ⬠(Bratti and Conti, 2012: 4). In addition to this, ââ¬Å"migration brings youth to ageing countries, and allows ideas to circulate in millions of mobile minds. That is good both for those who arrive with suitcases and dreams and for those who should welcome themâ⬠. (The Economist, 2011) A rather more technical research on this matter is conducted by Ozgen, Nijkamp and Poot (2012) who study the impact of size, skills and diversity of immigration on the innovativeness of host regions using the number of patent applications per million inhabitants from 170 regions in Europe for the periods 1991-1995 and 2001-2005. According to this study, there are five mechanisms through which immigration may boost innovation: ââ¬Å"the population size effectâ⬠; ââ¬Å"the population density effectâ⬠; ââ¬Å"the migrant share effectâ⬠; ââ¬Å"the skill composition effectâ⬠and ââ¬Å"the migrant diversity effectâ⬠. (Ozgen, Nijkamp and Poot, 2011:2). The first three mechanisms result from the fact that immigration increases the local aggregate demand. This boost in the aggregate demand could be met through an increase in the level and diversity of local production, which in the long run might need additional investment and thereby will encourage product and process innovation. Furthermore, local economy prosperity not only will generate firm growth but will also encourage additional start-up firms resulting into an innovation lift. Moreover, usually attracted to the large metropolitan areas with better job opportunities, migrants increase the urban population and thereby strengthen the forces of agglomeration which leads to greater innovation. (Ozgen, Nijkamp and Poot, 2011: 3). A more debated way through which the innovation system is enhanced by immigration refers to the skill composition effect on innovation. Given that the modern economy is in a constant quest for fresh ideas and better goods that would accelerate business growth, the global competition for highly-skilled migrants has gained magnitude. ââ¬Å"Their role in innovation may seem obvious: the more clever people there are the more ideas are likely to flourish, especially if they can be commercialised.â⬠(The Economist, 2009) Considerable empirical evidence for this is provided by Kerr who gathered data about the 8 million scientists who had acquired an American patent between 1975 and 2004. Hence, he found that the share of patents given to American-born scientists fell while the share of all patents awarded to immigrant scientists from China and India increased from 4.1% in the late 1970s to 13.9% between 2000 and 2004. (The Economist, 2009) Moreover, Kerr and William Lincoln (2008) ana lysed the way changes in the number of H-1B visa admissions reflected on patents in the years between 1995 and 2006. It is imperious to mention that H-1B visa is the United States work visa for skilled immigrants, which allows US companies to employ foreign workers in specialty occupations that require theoretical or technical expertise as well as the attainment of a bachelorââ¬â¢s degree or its equivalent as a minimum. Thus, they point out that ââ¬Å"the estimates suggest that a 10% growth in the H-1B worker population is associated with a 2% increase in patentingâ⬠(Kerr and Lincoln, 2008: 20) Bosetti, Cattaneo and Verdolini (2013: 1) predict that skilled immigration has a significant positive contribution not only to the knowledge creation in host countries as ââ¬Å"they add to the pool of skills in destination marketsâ⬠, but also enhances natives ââ¬Ëproductivity as the interaction of diverse cultures and approaches in problem solving and brain storming situations might give birth to new, original ideas. In order to support these predictions, they have studied the effect of skilled migrants on the number of patents applied for through the Patent Cooperation Treaty and citations of scientific publications, as proxies of innovation in a panel of twenty European countries from 1995 to 2008. Thus, in accordance with their initial prediction, Bosetti, Cattaneo and Verdolini (2013:11) found out that ââ¬Å"the variable measuring the stock of knowledge in a given country (stock of RD expenditure) exerts a positive and statistically significant effect on innovation. A 1 percent increase in the stock of RD expenditures is associated with a 0.6 percent and a 0.4 percent increase in patent application and citation, respectivelyâ⬠. In a similar vein, Hunt and Gauthier-Loiselle (2009) measure the likeness of skilled immigrants to enrich innovation and at what extent. They do so by evaluating the differences in patenting behaviour between immigrants and natives as well as the state-level determinants of patenting using a panel of data from 1940-2000 in the Unites States. The results show that a 1% increase in the college graduate immigrants implied 6.1% rise in patents per capita while 1% increase in the share of college natives raise patents per capita only by 3.5%. Furthermore, ââ¬Å"1.3 percentage point increase in the share of the population composed of immigrant college graduates and the 0.7 percentage point increase in the share of post-college immigrants both increased patenting per capita by about 12% (..). The 0.45 percentage point increase in immigrant scientists and engineers increased patenting per capita by about 13%.â⬠(Hunt and Gauthier-Loiselle, 2009:20). Hence they discover that one way ski lled immigrants could boost patenting per capita is by engaging in science and engineering as the knowledge and skills these occupations request are more easily transferable across countries. Skilled immigrants could also enrich patenting per capita, if an immigration policy regarding immigrantsââ¬â¢ selection according to their abilities and knowledge levels was introduced. This would attract more science and engineering orientated migrants and would encourage less skilled migrants to acquire higher education and engage themselves more into the innovation process. (Hunt and Gauthier-Loiselle, 2009: 2). Nevertheless, due to migration and globalisation, diversity has become an increasingly outstanding feature of todayââ¬â¢s world. This brings into discussion the fifth mechanism through which immigration can boost the innovation system, the migrant diversity effect, as an important link to innovation. A say on this matter had the European Commission (2008: 8), in their work regarding the diversity journey in search for talent, competitiveness and innovation: ââ¬Å"as innovation processes depend on harnessing creativity, and while dynamic as well as supportive systems of management can elicit the best from staff, like-minded people will usually produce like-minded results. Diversity in the workforce can, however, help companies to break this mould and the cycle of limited unilateral thinking and, in so doing, set them free to discover new products, markets, and ways of doing or leading businessâ⬠. Empirical evidence that confirms the positive linkage between cultural diversity and innovation is provided by Niebuhr (2006). She investigates the impact of a cultural diverse labour force in German regions on innovation, using a sample of 200 different nationalities. The results show cultural diversity to be beneficial to innovation: ââ¬Å"Due to their different cultural backgrounds, it is likely that migrants and native workers have fairly diverse abilities and knowledge. Thus, there might be skill complementarities between foreign workers and native in addition to those among workers of different qualification levels.â⬠(Niebuhr, 2006: 564). But are cultural diversity and immigration always beneficial to innovation? According to Bratti and Conti (2012: 4), cultural diversity might also cause difficulties in communication, especially when natives and immigrants do not speak the same language. This might reduce social capital and therefore act as an impediment to innovation and economic performance. In addition, Ozgen (2013: 92) finds as outcomes of cultural diversity, lower levels of trust and higher discrimination within firms, ââ¬Å"non-transferability of skillsâ⬠or ââ¬Å"non-recognition of qualificationsâ⬠which play as impediments in ideas exchange or the formation of new knowledge. Similarly, ââ¬Å"co-ethnic networks can lead to spatial or occupational segregation and clustering of migrant groups, which may also impede the contribution of immigrants to firm innovationâ⬠. Moreover, a few other situations which lie on the negative side of immigration could be observed. That would be the case of areas experiencing higher inflows of low-skilled or low educated migrants: ââ¬Å"unskilled immigration can have a negative effect by reducing social capital, creating communication problems among workers or pushing firms to lower their efforts to introduce product and process innovationsâ⬠. (Bratti and Conti, 2012:16). In order to uphold this statement, Bratti and Conti (2012: 22) evaluate the effect of low-skilled immigrants in Italian provinces on patent applications, as a proxy for innovativeness. Thus, they find evidence that there is a significant negative effect not only of low-skilled migrants, but also an overall negative effect of large inflows of immigrants on innovation: ââ¬Å"rising immigrantsââ¬â¢ share by 1 p.p. produces a 0.064 percent reduction in patentsââ¬â¢ applications per 1,000 inhabitants.â⬠This negative effect is proved to be mostly driven by the characteristics of immigrants who ââ¬Å"mainly appear as a source of low-skilled and cheap labour force, which is employed in traditional economic sectorsâ⬠(Bratti and Conti, 2012:11). Although it focuses especially on Italy, Bratti and Contiââ¬â¢s study is not necessarily a particular case, as their findings are also consistent with the Lewisââ¬â¢ work (2011: 1031) who has proved that areas rich in low-skilled immigrants areas adopted less machinery, giving technological change a slower evolution and: ââ¬Å"plants added technology more slowly between 1988 and 1993 where immigration induced the ratio of high school dropouts to graduates to grow more quicklyâ⬠. Hence, the substantial immigration boom from the end of the last century had a negative impact of knowledge formation and actively led to a slow growth in the supply of skills in the United States: ââ¬Å"only after the large wave of immigration in the 1980s did high-immigration ci ties become more unskilled than low immigration cities.â⬠(Lewis, 2011: 1031). On the other hand, there are also claims that even low-skill immigrants can indirectly enhance productivity gains and innovation: ââ¬Å"Even low-skill immigrants who start small businesses that stay small are important to the American economy. They provide low cost services and access to more goods. There are also second-order effects, for example someone who provides child or elder care cheaply provide an invaluable service. This allows natives to works outside of their homeâ⬠(The Economist, 2010). Similarly, Peri (2009: 17) has found a positive linkage between productivity gains and immigration in the United States in the years between 1960 and 2006, although the most majority of the immigrants in his sample were low-skilled and engaged in menial work. He proves that the inflow of unskilled migrants resulted in a more efficient allocation of skills and education to jobs amongst natives, thereby leading to an increase in the total factor productivity. Additionally, the negati ve effects of cultural diversity and unskilled immigrants could be overcome by properly exploiting the competencies of skilled immigrants as well as by attracting more highly educated immigrants. This could be achieved by introducing favourable immigration policies for high-skilled immigrants, in order to foster innovation and economic growth. Furthermore, free language courses and job-related training programs could be provided for immigrants in order to reduce language barriers and allow them to develop or upgrade their skills. To conclude, on theoretical grounds, there are several ways in which immigration and cultural diversity can affect both positively and negatively the innovation system. Given such a mixture of positive and negative effects, the overall impact of immigration on innovation should be considered in terms of empirical evidences. In this sense, this essay has presented a number of different studies and approaches from European countries, but also from the United States. What is more, five mechanisms through which immigration can boost innovation have been analysed. As opposed to this, several negative effects of cultural diversity and immigration with regards to the innovation process have been considered along with several ways these drawbacks could be overcome. Thus, all things considered, it could be consented that migration and cultural diversity represent an opportunity as much as a challenge, but if managed carefully it would lead to positive outcomes such as innovation, technologica l change, increasing productivity gains and ultimately to economic growth. References Bosetti V., Cattaneo C. and Verdolini E. (2012) ââ¬Å"Migration, Cultural Diversity and Innovation: A European Perspectiveâ⬠, FEEM Working Paper No. 69.2012. Online at: http://ssrn.com/abstract=2162836 (Accessed 14 January 2014) Bratti M. and Conti C. (2012) ââ¬Å"Immigration, Population Diversity and Innovation of Italian regionsâ⬠Online at: www.ecostat.unical.it/rd2013/Papers/Bratti_Conti.pdfââ¬Å½ (Accessed 12 January 2014) European Commission (2008) ââ¬Å"Continuing The Diversity Journey: Business Practices, Perspectives And Benefitsâ⬠European Union Publications Office, Luxembourg. Gordon I.R. and McCann P. (2005) ââ¬Å"Clusters, Innovation and Regional Development: An Analysis of Current Theories and Evidenceâ⬠, in Johansson B., Karlsson C. and Stough R., (eds.), ââ¬Å"Entrepreneurship, Spatial Industrial Clusters and Inter-Firm Networkâ⬠s , Edward Elgar, Cheltenham Hunt, J. and M. Gauthier-Loiselle (2008) ââ¬Å"How Much Does Immigration Boost Innovation?â⬠NBER Working Paper14312, National Bureau of Economic Research, Cambridge Mass. Online at: http://ftp.iza.org/dp3921.pdf (Accessed 12 January 2014) Kerr W.R.andLincoln W. F. (2008)ââ¬Å"TheSupplySideofInnovation:Hà ¢Ã¢â ¬Ã 1BVisaReformsandU.S.EthnicInventionâ⬠JournalofLaborEconomics. Online at: http://www.nber.org/papers/w15768 (Accessed 13th January 2014) Lewis, E. (2011) ââ¬Å"Immigration, skill mix, and capital skill complementarityâ⬠. The Quarterly Journal of Economics 126, 1029ââ¬â1069. Online at: http://ideas.repec.org/a/oup/qjecon/v126y2011i2p1029-1069.html (Accessed 9 January 2014) Niebuhr A. (2006): ââ¬Å"Migration and innovation: Does cultural diversity matter for regional RD activity?â⬠IAB discussion paper, No. 2006,14. Online at: http://www.econstor.eu/handle/10419/31908 (Accessed 11 January 2014) Ozgen C. (2013) ââ¬Å"Impacts of immigration and cultural diversity on innovation and economic growthâ⬠Online at: http://dare.ubvu.vu.nl/bitstream/handle/1871/47948/dissertation.pdf?sequence=1 (Accessed 13 January 2014) Ozgen, C., Nijkamp, P., Poot, J. (2011) Immigration and Innovation in European Regions IZA Discussion Papers 5676, Institute for the Study of Labor (IZA). Online at: http://ftp.iza.org/dp5676.pdf (Accessed 12 January 2014) Peri, G. (2009) ââ¬Å"The Effect of Immigration on Productivity: Evidence from US Statesâ⬠NBER working paper September 2009. Online at: http://www.nber.org/papers/w15507 Accessed 14 January 2014 The Economist (17 September 2010) ââ¬Å"Importing job growthâ⬠Online at: http://www.economist.com/blogs/freeexchange/2010/09/economic_growth (Accessed 10 January 2014) The Economist (19 November 2011) ââ¬Å"The magic of diasporasâ⬠. Online at: http://www.economist.com/node/21538742 (Accessed 10 January 2014) The Economist (5 March 2009) ââ¬Å"Give me your scientistsâ⬠¦Ã¢â¬ , Online at : http://www.economist.com/node/13234953 (Accessed10 January 2014) Venturini A. (2012) ââ¬Å"Innovation and Migrationâ⬠co-authored with F. Montobbio, C. Fassio, MPC Analytical Note, 2012/05. Robert Schuman Centre for Advanced Studies, San Domenico di Fiesole (FI): European University Institute, 2012. Pluripotent Stem Cells: Benefits, Properties and Uses Pluripotent Stem Cells: Benefits, Properties and Uses INTRODUCTION Pluripotent stem cells give rise to nearly all cells types of the body, like, muscle, nerve, heart, and blood. They hold huge promise for both research health care. The advance in human biology continues to generate interest among scientists, patients suffering from a wide range of diseases, including cancer, heart disease and diabetes, their families. Embryonic stem (ES) cells, is derived from inner cell mass of mammalian blastocysts they have the ability to grow for an indefinite period while maintaining pluripotency. These properties have led to hope that human Embryonic Stem cells might be useful to understand the disease mechanisms, to monitor effective and safe drugs, to treat patients of various diseases and injuries, such as juvenile diabetes and spinal cord injury. Cell culture is the one of the most important basic biomedical research. From many decades, many innumerable insights into both normal pathologic cellular processes have been gleaned by the study of human cells explanted in vitro. Primary human cells have a small life span in culture, there is a regulation of tissue formation, regeneration, and repair. Many human cell types have never closely been adapted for the expansion in vitro, and the lack of available models of normal pathologic tissue structure has render many new important questions in human growth and disease pathogenesis and it is hard to find. At present three types of methods have been reported to induce pluripotency artificially in mouse somatic cells. Embryonic stem like cells can also be recognized by long-term culture of bone marrow cells, and pluripotent stem cells can be generate adult germ cells, either by vitro culture of spermatogonial cells or by the parthenogenesis of unfertilized eggs. The capability to reprogram cells from the human blood will let the generation of patient-spec ific stem cells for the diseases. In this disease-causing somatic mutations are then restricted to the cells of the hematopoietic lineage. Depending on methods used, reprogramming of the adult cells to gain iPSCs may pose significant risk those could limit their use in humans. Many scientists around the world, announced the discovery of the method that could eliminate oncogenes after the induction of pluripotency, which will increase the potential use of iPSC in human disease. In April 2009, it was verified that generation of iPS cells is feasible without any genetic modification of the adult cell: a repetitive treatment of cells by means of certain proteins channelled into the cells viapoly-arginine anchorswas sufficient to induce pluripotency. Pluripotent stem cells are a unique scientific and medical source.The pluripotent stem cells are derived using non-Federal funds 8yat the beginning, embryos donated voluntarily by couples who are undergo fertility treatment in an vitro ferti lization clinic. Human embryonic stem cells isolated from more surplus embryos from in vitro fertilization clinics represent an immortal circulation of pluripotent cells that can theoretically generate any cell type inside the human body. PLURIPOTENT STEM CELLS PLURIPOTENT STEM CELLS are generated from adults cells where induced pluripotent stem cells is the part of pluripotent stem cells and it is also called as iPS cells or iPSCââ¬â¢s. Pluripotent stem cells give rise to nearly all of the cells types of body, like muscle, nerve, heart, and blood. Pluripotent stem cells are called master cells because they are able to make cells from all three body layers, so they can produce any cells or body needs to repair itself, it is called pluripotency. Pluripotent stem have promising future in the area of regenerative medicine because it it is different in effect on the cells of the body which are neurons, heart, pancreatic liver cells. It can help in the representation of single cell which can remain to lost the damage or diseased cells. IPSC they are similar to natural pluripotent stem cells, like embryonic stem cells in many ways, like the appearance of certain stem cell genes proteins,à chromatin methylationà patterns, doubling time,à embryoid bodyà formation,à teratomaà formation, viableà chimeraà formation, and potency and differentiability. Pluripotent stem cells EMBRYONIC STEM CELLS Embryonic stem cells is the most important type of pluripotent cells. Embryonic stem cells(ES cells) arepluripotentstem cellsthat are derived from theinner cell massof ablastocyst an early-stage preimplantationà embryo. Humanembryos reach theà blastocystà stage 4ââ¬â5 days postfertilization, at which time they consist of 50ââ¬â150 cells. From adult tissue iPSC has been derived. They cannot by pass the need of embryos but they can be matched in the patients which mean that pluripotent stem cells line will be present in the each individual. Without any risk of immune rejection autologous cells can be used for recognising the basic behaviour of disease present in the patients therapeutic transplants are not safe in iPSC technology. ESC that are appeared which have large domains of the genome that have a specific histone code, that are not found in more mature cells, which allows very fast inactivation or activation of gene expression. Embryonic stem cells arepluripotent th at are able todifferentiatein all derivatives of the three germ layers:ectoderm, endoderm, andmesoderm. It includes more than 220 cell types in the adultà body. Pluripotency distinguishes embryonic stem cells fromà adult stem cellsà found inà adults; while embryonic stem cells can produce all cell types in body, adult stem cells they are multipotentà and they can create only limited number of cell type. Human embryonic stem cell structure SOMATIC CELL NUCLEAR TRANSFER The somatic cell nuclear transfer (SCNT) means, transferring the nucleus from a somatic cell, any cell of the body, to an other cell, in this case itââ¬â¢s an egg cell. This kind of pluripotent stem cell called ntES cell, which has only been made successfully in the inferior animals. To make ntES cells in the human patients, an egg donor, would be needed. The process of transferring a differentnucleusinto the egg ââ¬Å"reprogramsâ⬠it to a pluripotent condition, reactivating full set of genes for creating all the tissues of the body. PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS iPSCs are introduced in a set of pluripotency associated genes or reprogramming factors in to a given cell kind. The original set of reprogramming factor are genes Oct4 (Pou5f1), Sox2, cMyc, and Klf4. It is a slow and unsufficient process which takes 1-2 weeks in mouse cells 3-4 weeks in human. It has efficiency of 0.01%- 0.1%. For improving the efficiency and time taken to get ipsc considerable changes have been done. In reprogramming factor, cell start to make colonies that look like pluripotent stem cells. Pluripotency is maintained by a combination of epigenetic, transcriptional and posttranscriptional mechanisms. PRODUCTION OF Ipsc CELLS GENERATION OF INDUCED PLURIPOTENT STEM cells. They divide culture donor cells. Transfect the stem cell-associated genes into cells by viral vectors. Harvest and culture the cells according to the Embryoic Stem cell culture by the use of mitotically in feeder cells. A small set of transfected cells become iPS cells generate ES-like colonies Generation of IPS cells Types of Pluripotent Stem Cells There are several types of pluripotent stem cells are Embryonic stem cells which are joined from the inner cell mass of blastocyst the embryos are produced from in vitro fertilisation, although this is important cause it eliminates the embryo, which could have been implanted for the formation of a baby. Embryonic germ cells which are obtained from the aborted foetuses and these pluripotent cells are copied from past cells. These past cells are those which can form sperm eggs. Embryonic carcinoma or the cancer cells which are cosset from tumour that sometimes are prevalent in a a foetus. DIFFERENCE BETWEEN TOTIPOTENT,à PLURIPOTENT, AND MULTIPOTENT Totipotent cells can form all the kind of cell in a body, in addition the extraembryonic, or the placental cells. Embryonic cells, the 1st couple of cell divisions following fertilization are the only cells that are totipotent cells. Pluripotent cells can also give rise to all of the type of cells that make up the body. Embryonic stem cells are called pluripotent. Multipotent cells can expand into more than 1 cell type, but they are more limited than the pluripotent cells, adult stem cells cord blood stem cells are often considered as multipotent. BENEFITS OF PLURIPOTENT STEM CELLS Pluripotent stem cells give a renewable basis of healthy cells tissues to treat many type of diseases similar to heart disease and diabetes. People who are burn those patients who suffer from autoimmune diseases like Parkinsons can give advantage from the usage of pluripotent stem cells. Pluripotent stem cells have large potential for treatment of diseases, because they give rise to majority of cell types in human body,which include muscle, blood, heart nerve cells. The use for pluripotent stem cells include the generation of cells tissues that are use in transplantation. Drug study research next method that pluripotent stem cells are beneficial. Animals are mostly used to measure the safety and use of drugs. Those drugs which are secure and used in development for testing on animals. TURNING PLURIPOTENT CELL INTO TREATMENT Over time, many techniques are developed, pluripotent stem cells could any one of the day allow doctors to create form, rejection-proof transplant to patch a scarred heart, revitalize damaged nerves or reboot an immune system which is not able of fighting infection. Doctors have first obtainedà pluripotentà stem cells that match the patient genetically through geneticà reprogramming,à nuclear transfer, or parthenogenesis. There are four critical steps: To growà pluripotentà stem cells that create a large quantity of healthy cells. Restore faulty genes,this would be needed if the cells are carrying a genetic disorder, such as sickle cell anemia which turn the stem cells into a specific cell kind or a tissue.A genetically healthy line ofà pluripotentà cells is recognized, they must be creating specialized kinds of cells and this process is called as differentiation. To transplant cells or tissue to the diseased or damaged organ or tissue,the cells will require to reach right part of the body, take hold and start to function. Scientists know how to deliver blood to the stem cells, but they still need to develop some effective delivery method for other cell types. Getting the pluripotent stem cell The cells can be made in one of several ways: Nuclear transferââ¬â By using a patientââ¬â¢s skin cell and then transferring it into an egg (possibly the patientââ¬â¢s own, or of an egg donor). Geneticà reprogrammingââ¬â By transforming a skin cell or blood cell or other cell from the patient to aà pluripotentà stem cell. Parthenogenesisââ¬â This is done by using unfertilized eggs. A woman may be able to give her own eggs to make stem cells that match her genetically, or draw on master banks of stem cells which are made from eggs. WHY ARE PLURIPOTENT STEM CELLS IMPORTANT? Pluripotent stem cells can be used to produce any cell or tissue the body might need to challenge a wide range of diseases, from diabetes to spinal cord injury, to childhood leukemia,or to heart disease. Pluripotentà stem cells can potentially be modified to provide a perfect genetic match for any patient. It means that the patient could get transplants of tissue and cells without matching tissue and tissue rejection problems. There is also no need to take powerful immune-suppressing drugs for the rest of their lives. Although there is time in achieving this, researchers have treated mouse models of human disease by using this strategy and hope that same can be done with human patients. Disease in a dish: Pluripotent stem cells create excellent laboratory models for studying how a disease unfolds, which further helps scientists to locate and track, very earliest disease-causing actions in cells. Immune deficiencies like type1 diabetes, muscular dystrophy, and myriad other disorders which are embedded in fetal development. In the lab, researchers monitor from where the first muscle cell comes from, or the first blood cell, and how this is different when the patient has a genetic disease. By the use of this information, doctors are able to correct the genetic defect before the disease advances. Applications: Pluripotentà stem cell has different characteristics that make it useful in different ways : Induced pluripotent cells(iPS cells) offer a unique chance to model many human disease and are already being used to make a lot of new discoveries about premature aging, disease,cancer, and more. They are made from a personââ¬â¢s own cells, they can be potentially manipulated to fix the defects that are causing disease and then used to create healthy cells for transplant that wonââ¬â¢t be rejected by the immune system. Embryonic stem cells(ES cells) are standard for the biological theory of pluripotency. Scientists are continuosly working with Embryonic Stem cells to study more about a cell with pluripotency and discover safe better ways to create iPS cells. Each type of ES cell is important for different reasons: ES cells made from donating early embryos are unique tools for the understanding of earliest stages of human development specific tissues form, because theyââ¬â¢re not modified to individual patients, their value is mainly in research. MEDICAL RESEARCH Disease modeling and drug development An attractive feature of the human iPS cells is their ability to derive them from adult patients for the study of cellular basis of human diseases. Since iPS cells have property of self-renewing and are pluripotent, they stand for a theoretically unlimited source of patient-derived cells which further can be turned into any kind of cell in the body. This is important because many other types of human cells which are derived from patients tend to stop rising after a few passages in laboratory culture. iPS have been generated for a broad variety of human genetic diseases, including common disorders such as Down syndrome and polycystic kidney disease. Organ synthesis A proof-of-concept by induced pluripotent stem cells (iPSCs) to make human organ for the transplantationà was reported by researchers of Japan. Human ââ¬Ëliverà budsââ¬â¢ (iPSC-LBs) were grown from a mixture of three different types of stem cells: Hepatocytesà (for liver function) coaxed from iPSCs Endothelial stem cellsà (to form lining ofà blood vessels) fromà umbilical cord blood Mesenchymal stem cellsà (to formà connective tissue). This new approach allows different cell types to self-organize into complex organ, mimicking the process inà fetal development. After growing in vitro for few days, the liver buds were transplanted into mice where the ââ¬Ëliverââ¬â¢ quickly connected with host blood vessels and then continued to grow. Tissue repair Embryonic cord-blood cells were induced to pluripotent stem cells by the use of plasmid DNA. Using cell surface endothelial/pericytic markersà CD31à andà CD146, researchers have identified vascular progenitor, which is high-quality, multipotent vascular stem cells. After the iPS cells were directly injected into theà vitreousà of damagedà retinaà of mice, the stem cells then engrafted into retina, grow repaired theà vascular vessels. Red blood cells In 2014,à type Oà red blood cellsà were synthesized at Scottish National Blood Transfusion Service from iPSC. The cells were induced to become aà mesodermà thenà blood cellsà then red blood cells. The final step was making them eject their nuclei mature properly. Type O rbcââ¬â¢s can be transfused into all patients. Each pint of the blood contain about 2 trillion red blood cells, although some 107 million blood donations are collected globally each year. Human transfusions were not expected to begin until 2016.
Thursday, September 19, 2019
The Ethics of Gene Therapy Essay -- Genetics Science Papers
The Ethics of Gene Therapy Francis Crick was quoted as saying, "We used to think that our fate was in our stars. Now we know that, in large measure, our fate is in our genes." Over 40 years ago, James Watson and Francis Crick discovered the structure of deoxyribonucleic acid (DNA). From this a new technique has evolved called gene therapy. Gene therapy was discovered in the 1980ââ¬â¢s a few years after researchers were already able to isolate specific genes from DNA. These techniques matured from the massive surge of ideas generated during the Recombinant DNA (rDNA) era. Gene therapy is basically the repairing of genes to correct for diseases that result from a loss or change in our genetic material. It is hard to comprehend the total effects of gene therapy, because we do not know if it should really be used? Who does it really benefit? And ultimately people can easily contemplate how it affects him or herself and their family. Therefore, to understand gene therapy some technical aspects need to be discuss ed. Technical aspects DNA is present in the nucleus of cells and is the genetic information of all organisms. The information of a human genome could be thought of in terms as an "encyclopedia", the 23 chromosome pairs would be "chapters", each gene a "sentence", three letter words "codons", which are spelled by each letter a "molecular nucleotide"--adenine (A), cytosine (C), guanine (G), and thymine (T) (Elmer-Dewitt, 1994). A gene acts as a blueprint and if these were blueprints for a house and the measurements were off by a foot, it has a huge influence on its total structure. This is the same for our bodies, if a slight alteration in our genetic information occurs like a mutation this could lead to a disease. D... ...tad. 1991. Principles of genetics. 8th ed. New York, NY: John Wiley & Sons, Inc. Gorman, C. 9 Oct 1995. Has gene therapy stalled? Time p. 62-63. Henderson, C.W. 5 May 1997. Researchers use gene therapy to protect human cell from HIV. AIDS Weekly Plus p. 16-17. Henderson, C.W. 5 May 1997. Hopkins researchers complete human gene therapy trial of kidney cancer vaccine. Cancer Weekly p. 29-30. Keenan, J.F. 20 Oct 1990. Human gene therapy: and ethical advance? America p. 262-263. Macer, D.R.J. Shaping genes: ethics, law and science of using new genetic technology in medicine and agriculture. Obtained from the WWW:http://www.biol.tsukuba.ac.jp/~macer/SG14.html Meiser, C. Medical ethics symposium on gene therapy. Obtained from the WWW:http://shsaa.org/Spectator/94n5/5gene.html Mulligan, R.C. 1993. The basic science of gene therapy. Science 260:926-932.
Wednesday, September 18, 2019
The Beast In the Cave Essay -- Literary Analysis, H.P. Lovecraft
ââ¬Å"Youââ¬â¢ve just crossed over into The Twilight Zoneâ⬠says Rod Serling before every episode of The Twilight Zone. A show that leaves itââ¬â¢s viewers in a macabre state. Instead of drawing a conclusion like most shows, the show usually ends mysteriously. It utilizes similar elements as other short half-hour shows, but goes about it in a different way. This outlandish style is seen in literature, more specifically short stories, as well. Even though other short stories employ the same literary devices, ââ¬Å"The Beast In The Caveâ⬠by H.P. Lovecraft is uniquely mysterious because of the storyââ¬â¢s suspenseful plot, compelling diction, and, most important, overshadowing theme. In ââ¬Å"The Beast In The Caveâ⬠, H.P. Lovecraft develops a suspenseful plot in order to build tension throughout the story that inevitably leaves the reader feeling disturbed and the story hanging. The plot itself is seems simple, but is complicated at the same time. Victoria Nelson talks about how Lovecraftââ¬â¢s stories tease the reader ââ¬Å"with the tantalizing prospect of utter loss of control, of possession or engulfment, while remaining at the same time safely contained within the girdle of a formalized, almost ritualized narrativeâ⬠. With ââ¬Å"The Beast In The Caveâ⬠, the protagonist faces only one conflict throughout the story making it a simple plot line; however, the predicament he is in provides the complexity and tension that Lovecraft creates in other stories as well. The complexity of the plot starts when the reader is introduced to a man lost in a cave and his source of light goes out and continues when the man realizes that ââ¬Å"starving would prove [his] ultimate fateâ⬠(1). Readers get a sense of hopelessness the man is feeling, and this is where the tensions begins to build. Alt... ...s. Design215 Inc., 2005-2011. Web. 10 Dec. 2011. . Fahy, Thomas Richard. The Philosophy of Horror. Lexington, KY: University of Kentucky, 2010. Print. King, Stephen. ââ¬Å"Gramma.â⬠Skeleton Crew. New York: Signet, 1986. 464-494. Lovecraft, H.P.. ââ¬Å"The Beast in the Cave.â⬠The Transition of H.P. Lovecraft: The Road to Madness. New York: Ballantine Books, 1996. 1-6. Nelson, Victoria. The Secret Life of Puppets. Cambridge, MA: Harvard UP, 2001. WNC Database. Web. 7 Dec. 2011. Tibbetts, John C. The Gothic Imagination: Conversations on Fantasy, Horror, and Science Fiction in the Media. Basingstoke: Palgrave Macmillan, 2011. Print. "The Use of Force--William Carlos Williams (1883-1963)." Classic Short Stories. B&L Associates, Bangor, Maine, U.S.A., 1995-2007. Web. 10 Dec. 2011. .
Ebonics :: essays research papers
Ebonics, which stands for Ebony + Phonics is a new term that Linguistics use to describe Black Dialect or Black English or many of the other names that it has been given for more that 350 years.. has been in the news recently but it is definitely not a new topic. Ebonics is a "language" that is a combination of "proper English" and a combination of African languages. Because of this combination a pattern was formed on how certain words are said such as this and that, would be pronounced dis and dat. In all words the "Th." sound sounded like a "D". There was also another pattern formed such as, no tense indicated in the verb, no "r" sound and no consonant pairs. These are just some of the many patterns that were created when Africans were forced to learn the English language.History states that around 1619, during the slave trade, ships collected slaves not just from one nation but from many nations. Although they were all Africans certain areas spoke different languages. Some Africans spoke Ibo, Yoruba and Hausa. They were then separated from each other and had to travel with people whom the could not understand. Captain William Smith wrote:...There will be no more likelihood of their succeeding in a plot...The slaves then had to learn English so that they could have some form of communication with their masters. Their native language and English would be combined and they would speak African-English pidgin. As the slaves began to learn how to communicate with each other, their words would merge into one common word that they could all understand. This is one of the ways that the language became mixed with English.When the African slaves had children they talked to them in African English pidgin. The slaves taught the children both languages so that they could communicate with the slaveowners and to other slaves. As each generation went on the Africans began to speak better English but there were still word that were never spoken correctly or said in proper form.In Georgia and other southern states there were blacks who were not brought from Africa and quite a few knew how to speak standard English. Around 1858 over 400 slave from Africa were brought straight to Georgia and none of them knew a word of English.(Smitherman) Being that these two groups merged together they adapted each others language whether it was correct or incorrectOn the east coast of America, the Blacks spoke a different degree of
Tuesday, September 17, 2019
Global economic development Essay
Evaluation of Gwladââ¬â¢s position within the global economic environment Swot analysis (Hewings, 1995) Strengths ââ¬â Gwlad as a country should focus on its administrative strength in the public sector. This would allow the country to delivery better services to the public in terms of quick processing of documentary and information needed by the citizens. Secondly, the country has seems to be one of the states in Western Europe which has highest number of population with diverse cultural activities. The Gwlad countryââ¬â¢s population diverse cultural work attracts a number of tourists. Weakness- the country offers low level services. It also shows that it has low manufacturing productions. In the overall results, the country has not developed to high production scale hence there is relatively low gross domestic productivity per head. Threats-the fact that the country has no ties with the other neighboring countries is vulnerable to incur high import and exports taxes. Other threats that may exits are those associated with shortages of vital good which are not produced locally. Opportunities- the country being in the region of Western Europe is most likely to be having advanced technology. This means that the wealthy in technology based activity can be worked to increase both the level of manufacturing as well as GDP per head within the country. Suggested policies to follow (Trogen, 1999) Technological policy- the group needs to utilize this policy in curbing the problem associated with the low productivity. In such a policy, the teams must emphasis both on innovation and invention work. Still many efforts should seek technical assistance from part of the globe where possible. Competition policy- in every kind of economic growth of region, amicable environment which allows competition is a must for spurring economic growth and development. This means that the local competition environment should be bestowed to all potential citizens in every particular sector of production. Apart from the local competitors, the policy should encompass other issues that would allow the external competition as part of initiating news ways of economic growth. activity2: yes! The issues that Dai has identified part of the main issues to look when deciding, marketing of Gwlad. It is clear that Dai has taken location, distance and labor as the main factors to consider in this marketing strategy. However, it should be known that security and resources available within the country plays important role in economic developments. Furthermore, the means of communicating available and the accessibility of they location goes hand in hand in determining the attraction external investors to come and invest in a particulars region. Overall, it would be very important to first consider the costs involved in the marketing of the Gwlad to the external world. While business activities are diverse, they entail a lot of interwoven interaction of many sectors. Any decision made within the government directly and indirectly affects the performance of the business. This form the fundamental issues as the governance procedure are final on business prosperity or failure. Hence, incentives and subsidiaries that are offered by the government in Gwlad perhaps would make the citizens and the foreignersââ¬â¢ interest to invest much aroused. Politics and policies enacted in the Gwlad also have enormous impact to business. Services and the rate at which they are available to interested business operators are also major part of marketing the state. This is because delay and bureaucracies in service and information acquisition are both derailing factors in business operations. Activity 3- (Meier, 2004): (I)-no! I do not agree that technological advances are the only key factors to economic development. There are other issues which are also of great importance. This is because economic development focuses on three or more area in its development. One of the focuses is the government policies. In such a field, economist examines issues which are concerned with price stabilities, employment and taxation as well as the policies set to have sustainable growth. as the economic development protocols are integrations of several factors, government operates on many areas which are directly in connection with economic development such monetary policies, trade transaction and taxation policies together with regulation pertaining to financial institutions. The second major area determining the economic development of a place or region is the manner in which policies dealing with services and infrastructures are set. These include highways, housing, security and still parks. Thirdly and the final section in which economic developments is determined is directed to policies of job creation, retention and expansion, technology transfers and marketing as well as neighborhood development. In such consideration, it is vivid that the economic development is not achieved only through technology advancement. Certain factors are physical factors which are needed for the operations of certain economical activities. Other factors are human based availabilities like policy making that affects the economic growth of an area. For instance, trade restriction may be major factor contributing to low rates of economic developments due to lack of competitive environments. Abolition o such trade restrictions create a better environment for potential foreign investors. Financial factors have been seen as prominent factors that enable economic developments as can be revealed in most developing and underdeveloped countries. Their economics developed rates are not associated with inadequate funding for projects based on economic development and projects on research work which brings about technical advances. Thus, human policy factors, financial status factors and technical factors are all attribute to economic development As from the above revelation, I do not agree the three sectors are the core that economic policy should concentrate in. Energy; environmental, telecommunication and ICT are not the core that can bring economic growth in a country without integrating changes in governance. Management of any organization/ institutions is vital. Thus the inclusion of effective management and services delivery would enhance proper utilization of the resources available in the three sectors which would lead to economic growth. Activity4-(Isard, 1985): analysis of inward investment attraction, domestic company development and combination strategies Inward investment Strengths- depending on the financial ability of the surrounding neighbor countries, this form one of the greatest strong hold in which the foreigners can capitalized in. this means that they would be able to provided financial services and their products. Weakness- the fact that the country has got no ties in trade transactions such as free trades areas with the neighboring states, many inwards investments are likely to be heavily taxed and barred in their operations. Generally, unfair treatment to the inward investors is likely to cause low rate of investment. Opportunities- the fact that most neighbors have advanced technology and also they are able to having greater GDP than the Gwlad, it means that the inwards investment would be able to replicate similar productivity phenomenon making trading a competitive issue in the country. This means that the inward investors would enjoy the advantages of large scale production (Pleeter,1990) Threats- following the inwards investors interacting with the locals, there is that possible of technology transfer which the local would gain an advantage of learning the new techniques and therefore begin producing local products that would halt the utilization of the investorsââ¬â¢s products Domestic company development: strength- the country seems to be lagging behind in all the areas. This implies it has very limited strengths on which it can take an advantage over its neighbors. (Peterson, 2001) Weakness- the country is portrayed to lag behind in general productivity which implies that their is low trade activities in the regions Opportunities- the country having a score of learned individuals within its boundaries can be utilized both in the management level to bring technology to its required standards enhancing production which is a core to level of trade activities in country. Threats- the domestic company development are likely to be threaten when the country goes to inwards investment. The inward investors being more competitive than the domestic companies would render the local companies uncompetitive in terms of quality of products, price and in marketing strategies. For the above consideration of the analysis, I would choose the combined strategy the main reason for choosing this particular mode is because, with proper policy formulation and enactment for both internal and external investor companies, there are high chances of mutual benefits. Technology advancement, financial investment availability leading to higher production of the products would enhance the general growth of the economy of the country. Activity 5:- (Bulmer-Thomas, 1992, Leistritz, 1991): the GDEADââ¬â¢s members are supposed to come up with policies which would enable low cost in the supply chains. These policies includes:- The policy of strategic vision and concrete actions in cooperating in the supply of the material and the distribution of the products to all parts on the country Reduction of taxes in the products produced locally the investors Development of local infrastructures that will enhance logistics from one area to another Recruitment and training of human resources to enable smooth distribution of the products Policies to enable persuasion of U. S multinationals in financing, marketing and R&D in Gwlad The GDEAD must come with policy that allows globalization of market in Gwlad The team should use merger systems of the a few industries so that they begin venturing in to the same market in which the multinationals are operating to break monopoly of the U. S automotive companies. The team should advocate for new methods of technology in information and communication to enhance global advertising both from local and multinational companies. Activity 6:- (Dewhurst, 1991) Pros of the EU are that the EU members have several methods in which its negotiations and terms are based. First, the EU group has strong negotiating power than any other union. This means that the pooling together of efforts in the negotiating process makes the members to have great influence in international trade. Its members are said to be first in the leading in foreign direct investment. The united stated are depicted as the second while they remain the first for foreign investment. While the EU operations are undertaken within the 130 countries, it commands a relative open economy that accounts over 14% of the international trade of its gross domestic products. In comparison with the United States gross domestic products, it commands of 12%. It implies that the EU association with the Gwlads is of more advantageous than joining any other of the above state. (Bull, 1995) I would make arrangements of integration type in joining EU for the Gwlad. This because the EU integration would protect the local first and then from the integration the other collaborating states would have an influence in Gwlad in political, security, technology and other areas in which economic issues are connected. He Gwlad would be changed in its institutions through the established rules and regulations of the EU integration that sets the culture and philosophical basis of government as well as other authoritative bodies which could change economic Institutions. However, free trade would definitely bring in unfair competitions to the locals industries and communities leading to the poorly performing ones. (Dewhurst, 1991) Activity7:- (Grady, 1989) The clusters economic development established in this region is not of best nature. Locating an economic zone far 100km from each other is like creation of monopoly of the various institutions established. Secondly, the interaction of the various institutions when they are far from one and yet they are no quicker means of communication implies less information transfers/ ineffectiveness or delay actions would be frequent. This implies especial in the health, bioscience, financial services/ products and professional services. Similar disadvantages would exist in creative, automotive and aerospace zone. However, the distance would be of advantage to automotive and aerospace in advancing the technological world as this would be determined by increased needs to travel from one zone to another. In organizing the above sectors, I will use different policy as they all differ in the application of creating and reduction economic growth. While the bioscience and the health sectors are there for the purpose of ensuring fitness of the community, the automotives and aerospace are established for saving time in production. Thus health and bioscience would policies towards health facilities and proper nutrition while the latter two would venture policy on technology of speedy safer means. Activity8:- (Grady, 1989, Brace, 1993) Costs and benefits of meeting the demands of the aerospace industry The costs of the meeting the demands of the aerospace industry involves the productions costs. This would require importation of new materials for the manufacture of the aerospace device. Second is the maintenance cost, which will be cut through the use of the correct quality materials. Thirdly is the training cost which will be an essence in having potential skilled human resources and engineers who work on the technological manufacture of the aero plane as well As maintaining them. Finally, the country would have to invest in R &D that would enhance development of modern aerospace using the most advanced technologies than any other competing companies Suggested policy to GDEAD: (Hunter, 1999, Walsh, 1996) The GDEAD should come u p with a policy for which given the current financial situation, it would be able to meet the same demands, but through institution establishment and collaboration with the industry, it would support them in the research work. Reference: Brace, P. (1993). State government and economic performance: Johns Bull, A. (1995): The economics of travel and tourism: Longman. Bulmer-Thomas, V. (1992): Input-output analysis in developing countries: Wiley Dewhurst, J. (1991): Regional input-output modeling / new development and interpretation: Avebury Grady, D. (1989): Governors and economic development policy: vol. 17, pp 870-84 Hewings, G. (1995): Regional input-output analysis, Beverly Hills: Sage Publications Hopkins University Press Hunter, K. (1999): Interest groups and state economic development policies: Praeger Publishers Isard, W. (1985): Introduction to regional science: Prentice Hall. Leistritz, F. (1991): The socioeconomic impact of resource development: Westview Press. Meier, G. (2004): Leading issues in economic development. Oxford Peterson, W. (2001): technology, planning, and Development: Oxford University Press. Pleeter, Saul (1990). Economic impact analysis: Boston: Maritinus Nijhoff Publishing Trogen, P. (1999): Which economic development policies work: retrieved from http:// University Press Walsh, R. (1996): Recreation economic decisions: Venture Publishing, Inc www. spaef. com, on 1st December 2008
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